Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic
alterations in cancer often serve as potent surrogates for genetic mutations. Normal …

The epigenome, which comprises chromatin, associated proteins, and the pattern of
covalent modification of DNA by methylation, sets up and maintains gene expression …

The observation that cancer cells suffer profound alterations in the DNA methylation profile,
with functional consequences in the activity of key genes, together with the recognition that …

For decades, chromatin was considered to be an inert structure whose only role was the
compacting and confining of DNA inside the eukaryotic nucleus. However, tremendous …

The disruption of genomic DNA methylation patterns was the first epigeneticabnormality to
be described in human cancer. This imbalance involves thepromoter CpG island …

The dramatic re-organization of the cancer cell nucleus creates telltale morphological
features critical for pathological staging of tumors. In addition, the changes to the mutational …