Renal fibrosis is a common irreversible process of chronic kidney disease (CKD)
characterized by uncontrolled deposits of extracellular matrix, replacement of cellular …

Elevated expression of the multifunctional cytokine transforming growth factor β1 (TGF-β1) is
causatively linked to kidney fibrosis progression initiated by diabetic, hypertensive …

Transforming growth factor beta (TGF-β) has been recognized as an important mediator in
the genesis of chronic kidney diseases (CKD), which are characterized by the accumulation …

Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic
diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream …

Background/Aims: The cellular and humoral factors involved in the development and
progression of renal scarring have not been fully investigated. Transforming growth factor-β …

Chronic kidney disease (CKD) affects more than 20 million people in the United States and
the global burden of this disorder is increasing. Many affected individuals will progress to …

Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix
(ECM) that frequently occurs in membranous and diabetic nephropathy. The result of renal …

A number of molecules utilizing different TGF-β1-induced signaling pathways are 6 involved
that activate a wide variety of cells leading to a terminal event known as “scarring or 7 …

Renal fibrosis is a hallmark of chronic kidney disease. Although considerable achievements
in the pathogenesis of renal fibrosis have been made, the underlying mechanisms of renal …

Chronic kidney diseases are emerging as a worldwide public health problem. The
progression of kidney diseases closely correlates with the accumulation of extracellular …