A well‐coordinated facilitation–inhibition control of motor neuronal persistent inward
currents (PICs) via diffuse neuromodulation and local inhibition is essential to ensure motor …

Ageing is a natural process causing alterations in the neuromuscular system, which
contributes to reduced quality of life. Motor unit (MU) contributes to weakness, but the …

Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of
motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by …

Key points Motor neurons are the output neurons of the central nervous system and are
responsible for controlling muscle contraction. When initially activated during voluntary …

This study investigated the effects of high-intensity resistance training on estimates of the
motor neuron persistent inward current (PIC) in older adults. Seventeen participants …

Nervous system deterioration is a primary driver of age‐related motor impairment. The motor
neurones, which act as the interface between the central nervous system and the muscles …

Age-related deterioration within both motoneuron and monoaminergic systems should
theoretically reduce neuromodulation by weakening motoneuronal persistent inward current …

Persistent inward current (PIC) plays an important role in setting the input-output gain of
motoneurons. In humans, these currents are estimated by calculating the difference between …

Persistent inward currents (PICs) are present in many types of neurons and likely have
diverse functions. In spinal motoneurons, PICs are especially strong, primarily located in …

Spinal motoneuron firing depends greatly on persistent inward currents (PICs), which in turn
are facilitated by the neuromodulators serotonin and noradrenaline. The aim of this study …