Our conception of programmed cell death has expanded beyond apoptosis to encompass
additional forms of cell suicide, including necroptosis and pyroptosis; these cell death …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

Necroptosis is one the best‐characterized forms of regulated necrosis. Necroptosis is
mediated by the kinase activities of receptor interacting protein kinase‐1 and receptor …

Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment,
with notable therapeutic effects on certain cancer types. Despite their significant potential …

The host immune system is continuously exposed to dying cells and has evolved to
distinguish between cell death events signaling potential threats and physiological …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

The manner in which cells die is believed to have a major impact on the nature of immune
responses to their released Ags. In this study, we present the first direct analysis of tumor …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …