Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms
involved by studying N-methyl-d-aspartate (NMDA) toxicity in cultured murine …

The ability of cannabinoid CB1 receptors to influence glutamatergic excitatory
neurotransmission has fueled interest in how these receptors and their endogenous ligands …

Excitotoxic neuronal death underlies many neurodegenerative disorders. Because
cannabinoid receptor agonists act presynaptically to inhibit glutamate release, we examined …

Cannabinoid receptor agonists act presynaptically to inhibit the release of glutamate.
Because other drugs with this action are known to reduce excitotoxicity, we tested several …

Exogenously administered cannabinoids are neuroprotective in several different cellular
and animal models. In the current study, two cannabinoid CB1 receptor ligands (WIN 55,212 …

Preparations from Cannabis sativa (marijuana) have been used for many centuries both
medicinally and recreationally. However, the chemical structure of their active components …

CB1 cannabinoid receptors (CB1Rs) are involved in protecting the brain from ischemia and
related disorders. However, the underlying protective mechanisms are incompletely …

Although the activation of cannabinoid receptor-1 (CB1) receptors by cannabinoids is known
to inhibit neuronal hyperexcitability and reduce excitotoxic cell death, the mechanistic links …

Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain
against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of …

Endocannabinoids act as retrograde messengers that, by inhibiting neurotransmitter release
via presynaptic CB1 cannabinoid receptors, regulate the functionality of many synapses. In …