Escaping deleterious immune response in their hosts: lessons from trypanosomatids

A Geiger, G Bossard, D Sereno, J Pissarra… - Frontiers in …, 2016 - frontiersin.org
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania,
protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and …

Host immune responses and immune evasion strategies in African trypanosomiasis

C Onyilagha, JE Uzonna - Frontiers in immunology, 2019 - frontiersin.org
Parasites, including African trypanosomes, utilize several immune evasion strategies to
ensure their survival and completion of their life cycles within their hosts. The defense factors …

How the African trypanosomes evade host immune killing

B Namangala - Parasite immunology, 2011 - Wiley Online Library
Unlike other protozoan parasites, African trypanosomes never enter the host cell at any
stage of their development. Instead, these parasites swim freely in the immunologically …

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity

B Stijlemans, G Caljon, J Van Den Abbeele… - Frontiers in …, 2016 - frontiersin.org
The diseases caused by African trypanosomes (AT) are of both medical and veterinary
importance and have adversely influenced the economic development of sub-Saharan …

Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake

J Cnops, S Magez, C De Trez - Parasitology, 2015 - cambridge.org
African trypanosomes have been around for more than 100 million years, and have adapted
to survival in a very wide host range. While various indigenous African mammalian host …

Immune evasion strategies of trypanosomes: a review

A Oladiran, M Belosevic - Journal of Parasitology, 2012 - meridian.allenpress.com
Trypanosomes are digenetic protozoans that infect domestic and wild animals, as well as
humans. They cause important medical and veterinary diseases, making them a major …

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune …

S Magez, JE Pinto Torres, E Obishakin… - Frontiers in …, 2020 - frontiersin.org
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game
animals around the world. Through co-evolution with the mammalian immune system …

Modulation of innate immunity by African trypanosomes

DM Paulnock, BE Freeman, JM Mansfield - Parasitology, 2010 - cambridge.org
The experimental studies of Brucei group trypanosomes presented here demonstrate that
the balance of host and parasite factors, especially IFN-γ GPI-sVSG respectively, and the …

Salivarian trypanosomes have adopted intricate host-pathogen interaction mechanisms that ensure survival in plain sight of the adaptive immune system

S Magez, JE Pinto Torres, S Oh, M Radwanska - Pathogens, 2021 - mdpi.com
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game
animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human …

African trypanosomes undermine humoral responses and vaccine development: link with inflammatory responses?

B Stijlemans, M Radwanska, C De Trez… - Frontiers in …, 2017 - frontiersin.org
African trypanosomosis is a debilitating disease of great medical and socioeconomical
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …