Simple Summary For laboratory mice, handling methods used for routine husbandry and
procedures can cause stress, particularly if tail handling methods are used. We first sought …

Millions of mice are used every year for scientific research, representing the majority of
scientific procedures conducted on animals. The standard method used to pick up laboratory …

Handling of laboratory mice is essential for experiments and husbandry, but handling can
increase anxiety in mice, compromising their welfare and potentially reducing replicability …

Refined handling improves laboratory mouse welfare and research outcomes when
compared to traditional tail handling, yet implementation does not seem to be widespread …

Handling can stimulate stress and anxiety in laboratory animals that negatively impacts
welfare and introduces a confounding factor in many areas of research. Picking up mice by …

Laboratory animals are subjected to multiple manipulations by scientists or animal care
providers. The stress this causes can have profound effects on animal well-being and can …

Handling stress is a well-recognised source of variation in animal studies that can also
compromise the welfare of research animals. To reduce background variation and maximise …

Studies in mice have shown that less aversive handling methods (eg tunnel or cup handling)
can reduce behavioural measures of anxiety in comparison to picking mice up by their tail …

Handling is a well-known source of stress to laboratory animals and can affect variability of
results and even compromise animal welfare. The conventional tail handling in mice has …

Handling laboratory animals for husbandry and other procedures can be an important
source of anxiety and stress, compromising animal welfare as well as the reliability of …