Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …

Emerging insights into cellular senescence highlight the relevance of senescence in
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …

The adverse effects of aging of other organs (ovaries at menopause) on the skeleton are
well known, but ironically little is known of skeletal aging itself. Evidence indicates that age …

Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

Estrogen deficiency is a seminal mechanism in the pathogenesis of osteoporosis. Mounting
evidence, however, establishes that cellular senescence, a fundamental mechanism that …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

Background. Although data from rodent systems are extremely useful in providing insights
into possible mechanisms of age-related bone loss, concepts evolving from animal models …

Aging is a major risk factor for osteoarthritis and osteoporosis. Yet, these are not necessary
outcomes of aging, and the relationship between age-related changes in bone and cartilage …