Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related
progressive disease characterized by reduced bone mass and increased risk of fractures. At …

The development of osteoarthritis (OA) correlates with a rise in the number of senescent
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …

Skeletal aging is accompanied by decreased cancellous bone mass and increased
formation of pores within cortical bone. The latter accounts for a large portion of the increase …

Aging is associated with increased cellular senescence, which is hypothesized to drive the
eventual development of multiple comorbidities. Here we investigate a role for senescent …

Skeletal aging begins after peak bone mass is reached; progressive bone loss then occurs.
Peak bone mass may occur at different ages in different skeletal sites and varies between …

Although a decline in bone formation and loss of bone mass are common features of human
aging, the molecular mechanisms mediating these effects have remained unclear. Evidence …

Aging research has undergone unprecedented advances at an accelerating rate in recent
years, leading to excitement in the field as well as opportunities for imagination and …

The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …