With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Osteoporosis is substantially an age-related condition characterized by low bone mass and
increased bone fragility, putting the patients at risk of fractures, which are major causes of …

A decline in bone mass leading to an increased fracture risk is a common feature of age-
related bone changes. The mechanisms underlying bone senescence are very complex and …

Context: Age-related bone loss is associated with progressive changes in bone remodeling
characterized by decreased bone formation relative to bone resorption. Both trabecular and …

Mice are increasingly used for investigation of the pathophysiology of osteoporosis because
their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike …

Cellular senescence plays an important role in human diseases, including osteoporosis and
osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory …

The proliferative capacity and cellular and biochemical characteristics of human trabecular
bone osteoblasts were analysed throughout their replicative lifespan in vitro. Like several …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

All factors influencing the material composition and structure of bone do so through the final
common cellular pathways of modeling and remodeling. During growth, modeling, the …