Knowledge of the underlying mechanisms of osteoporosis in older adults has significantly
advanced in recent years. There is an acute loss of bone mineral density in the peri …

The most plausible purpose for bone remodeling is to prevent excessive aging of bone,
which can cause osteocyte death and increase susceptibility to fatigue microdamage. The …

Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but
chronic senescence, as in aging, can contribute to the development of age-related tissue …

The worldwide prevalence of type 2 diabetes (T2D) is increasing. Despite normal to higher
bone density, patients with T2D paradoxically have elevated fracture risk resulting, in part …

Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to
age-related pathologies,,, presumably through their secretion of factors contributing to the …

Osteoporosis is an age-related progressive bone disease. Recent advances in epigenetics,
cell biology, osteoimmunology, and genetic epidemiology have unraveled new mechanisms …

The differentiation of muscle connective tissue cells into chondroblasts and osteoblasts in
implants of demineralized bone matrix in rodents was first described in 196524 and has …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Bone homeostasis is securely controlled by the dynamic well‐balanced actions among
osteoclasts, osteoblasts and osteocytes. Osteoclasts are large multinucleated cells that …

Complex interactions among cells of the monocyte-macrophage-osteoclast lineage and the
mesenchymal stem cell-osteoblast lineage play a major role in the pathophysiology of bone …