Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including
bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction …

It is well known that the underlying mechanisms of osteoporosis in older adults are different
than those associated with estrogen deprivation. Age-related bone loss involves a gradual …

Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …

It is well accepted that age is an important contributing factor to poor cartilage repair
following injury, and to the development of osteoarthritis. Cellular senescence, the loss of …

Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic
bone resorption not compensated by osteoblastic bone formation. This causes bones to …

Women gradually lose bone from the age of~ 35 years, but around menopause, the rate of
bone loss escalates due to increasing bone resorption and decreasing bone formation …

The term" fragility fractures" refers to fractures that occur in response to the minor kinds
of'trauma that are a part of everyday life. Fragility fractures are generally considered to have …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Chemotherapy is important for cancer treatment, however, toxicities limit its use. While great
strides have been made to ameliorate the acute toxicities induced by chemotherapy, long …

Osteoarthritis (OA) is a common form of degenerative joint disease. Aging process is
supposed to be a leading predictor for developing OA. In this review, we have discussed the …