It is well known that bone loss accompanies aging in both men and women and contributes
to skeletal fragility in the older population, but changes that occur to the bone tissue matrix …

Clinical experience gives rise to the impression that there are differences in fracture healing
in different age groups. It is evident that fractures heal more efficiently in children than in …

The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Bone healing involves complex biological pathways and interactions among various cell
types and microenvironments. Among them, the monocyte–macrophage–osteoclast lineage …

Bone is remodeled continuously during adulthood through the resorption of old bone by
osteoclasts and the subsequent formation of new bone by osteoblasts. These two closely …

Osteoporosis is a multifactorial disorder associated with low bone mass and enhanced
skeletal fragility. Although most prevalent in older females, some men are also at high risk …

Bone mass in the skeleton is dependent on the coordinated activities of bone-forming
osteoblasts and bone-resorbing osteoclasts in discrete bone multi-cellular units …

Osteoporosis is a major cause of morbidity in older people. There are a large number of risk
factors for the development of senile osteoporosis. Howeover, recent discoveries suggest …

Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone
loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to …

Age-related fragility fractures are an enormous public health problem. Both acquisition of
bone mass during growth and bone loss associated with ageing affect fracture risk late in …