Complex cortical malformations associated with mutations in tubulin genes: TUBA1A,
TUBA8, TUBB2B, TUBB3, TUBB5 and TUBG1 commonly referred to as tubulinopathies, are …

Mutations in alpha-and beta-tubulins are increasingly recognized as a major cause of
malformations of cortical development (MCD), typically lissencephaly, pachygyria and …

Polymicrogyria and lissencephaly are causally heterogeneous disorders of cortical brain
development, with distinct neuropathological and neuroimaging patterns. They can be …

A spectrum of neurological disorders characterized by abnormal neuronal migration,
differentiation, and axon guidance and maintenance have recently been attributed to …

Complex cortical malformations associated with mutations in tubulin genes are commonly
referred to as “Tubulinopathies”. To further characterize the mutation frequency and …

A large number of genes encoding for tubulin proteins are expressed in the developing
brain. Each is subject to specific spatial and temporal expression patterns. However, most …

The fine tuning of proliferation and neurogenesis, neuronal migration and differentiation and
connectivity underlies the proper development of the cerebral cortex. Mutations in genes …

Tubulins, and microtubule polymers into which they incorporate, play critical mechanical
roles in neuronal function during cell proliferation, neuronal migration, and postmigrational …

The tubulin gene family is mainly expressed in post-mitotic neurons during cortical
development with a specific spatial and temporal expression pattern. Members of this family …

The formation of the mammalian cortex requires the generation, migration, and
differentiation of neurons. The vital role that the microtubule cytoskeleton plays in these …