A wide variety of definitions are used for Treatment Resistant Depression (TRD), considering
various criteria and different concepts. Some of the key issues are: the diagnosis, the …

Treatment-resistant depression (TRD) typically refers to inadequate response to at least one
antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

Abstract Treatment-resistant depression refers to major depressive disorder, treatment of the
disorder, and failure to obtain an “acceptable” outcome. Regarding the disorder, the …

OBJECTIVE: To summarize and discuss the conceptual and operational definitions of
treatment resistant/refractory depression (TRD) by systematically reviewing randomized …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Objective: No universal definition for treatment-resistant depression (TRD) exists. This lack
of consensus reduces the generalizability of study findings and limits the ability to study …

Objectives: Very few studies have investigated clinical features associated with treatment-
resistant depression (TRD) defined as failure of at least 2 consecutive antidepressant trials …

Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …

Background Major depressive disorder is a common, recurrent, disabling and costly disorder
that is often severe and/or chronic, and for which non-remission on guideline concordant first …