Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …

Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …

This review article addresses the biological factors that influence:(i) the acquisition of
alcohol intake;(ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like …

Rationale Using a preclinical model based on the Alcohol Deprivation Effect (ADE), we have
reported that N-Acetylcysteine (NAC) can prevent the relapse-like drinking behaviour in long …

Alcoholism is rampant in modern society and some antioxidant compound could perhaps be
useful to reduce the damage done by alcohol consumption and abstinence. The present …

Alcoholism has been characterized as a systemic pro-inflammatory condition and alcohol
withdrawal has been linked to various changes in the brain homeostasis, including oxidative …

Rationale Glutamate systems play an important role in the abuse related effects of alcohol. n-
Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a range of alcohol …

Background Life expectancy is greatly reduced in individuals presenting alcohol use
disorders and chronic smoking. Literature studies suggest that common mechanisms may …

Abstract N-acetylcysteine (NAC), a glutamate-modulating agent with antioxidant and anti-
inflammatory properties, has been considered as a potential anti-addictive drug. Beneficial …

Chronic ethanol exposure is known to cause neuronal damage in both humans and
experimental animal models. Ethanol treatment induces neurotoxicity via the generation of …