N-Acetylcysteine and acetylsalicylic acid inhibit alcohol consumption by different mechanisms: combined protection
Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …
been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present …
Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress …
Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …
Acquisition, maintenance and relapse-like alcohol drinking: lessons from the UChB rat line
This review article addresses the biological factors that influence:(i) the acquisition of
alcohol intake;(ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like …
alcohol intake;(ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like …
N-Acetylcysteine normalizes brain oxidative stress and neuroinflammation observed after protracted ethanol abstinence: a preclinical study in long-term ethanol …
S Fernández-Rodríguez, MJ Cano-Cebrián… - …, 2023 - Springer
Rationale Using a preclinical model based on the Alcohol Deprivation Effect (ADE), we have
reported that N-Acetylcysteine (NAC) can prevent the relapse-like drinking behaviour in long …
reported that N-Acetylcysteine (NAC) can prevent the relapse-like drinking behaviour in long …
Effects of N-acetylcysteine on alcohol abstinence and alcohol-induced adverse effects in rats
FRF Seiva, JF Amauchi, KKR Rocha, GA Souza… - Alcohol, 2009 - Elsevier
Alcoholism is rampant in modern society and some antioxidant compound could perhaps be
useful to reduce the damage done by alcohol consumption and abstinence. The present …
useful to reduce the damage done by alcohol consumption and abstinence. The present …
N-acetylcysteine Prevents Alcohol Related Neuroinflammation in Rats
R Schneider, S Bandiera, DG Souza, B Bellaver… - Neurochemical …, 2017 - Springer
Alcoholism has been characterized as a systemic pro-inflammatory condition and alcohol
withdrawal has been linked to various changes in the brain homeostasis, including oxidative …
withdrawal has been linked to various changes in the brain homeostasis, including oxidative …
Influence of n-acetylcysteine maintenance on the pharmacodynamic effects of oral ethanol
WW Stoops, JC Strickland, LR Hays… - Pharmacology …, 2020 - Elsevier
Rationale Glutamate systems play an important role in the abuse related effects of alcohol. n-
Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a range of alcohol …
Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a range of alcohol …
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar‐Derived UChB Rats: Inhibition by N‐Acetylcysteine
Background Life expectancy is greatly reduced in individuals presenting alcohol use
disorders and chronic smoking. Literature studies suggest that common mechanisms may …
disorders and chronic smoking. Literature studies suggest that common mechanisms may …
N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats
R Schneider Jr, CF Santos, V Clarimundo, C Dalmaz… - Alcohol, 2015 - Elsevier
Abstract N-acetylcysteine (NAC), a glutamate-modulating agent with antioxidant and anti-
inflammatory properties, has been considered as a potential anti-addictive drug. Beneficial …
inflammatory properties, has been considered as a potential anti-addictive drug. Beneficial …
Co-treatment with anthocyanins and vitamin C ameliorates ethanol-induced neurodegeneration via modulation of GABAB receptor signaling in the adult rat brain
H Badshah, T Ali, A Ahmad, MJ Kim… - CNS & Neurological …, 2015 - ingentaconnect.com
Chronic ethanol exposure is known to cause neuronal damage in both humans and
experimental animal models. Ethanol treatment induces neurotoxicity via the generation of …
experimental animal models. Ethanol treatment induces neurotoxicity via the generation of …