Antigen presenting cells (APCs) initiate CD4+ T cell-mediated immune responses via the
presentation of protein antigens on MHC class II (MHCII) molecules. Numerous APCs are …

To initiate an adaptive immune response, rare antigen-specific naïve CD4+ T cells must
interact with equally rare dendritic cells (DCs) bearing cognate peptide-MHC complexes …

To initiate an adaptive immune response, rare antigen-specific naive CD4+ T cells must
interact with equally rare dendritic cells (DCs) bearing cognate peptide-major …

METHODS: We analyzed the APC requirements for CD4+ T cell priming by employing
transgenic mice and/or bone marrow chimeras that have restricted MHC class II expression …

Activation of CD4+ T cells by APCs occurs by multiple Ag recognition events including the
exchange of costimulatory signals and cytokines. Additionally, the T cells acquire APC …

Conventional dendritic cells (cDCs) are potent antigen-presenting cells that consist of
developmentally, phenotypically, and functionally distinct subsets. Following immunization …

Professional antigen‐presenting cells (APC) are able to process and present exogenous
antigen leading to the activation of T cells. Antigen–immunoglobulin (Ig) G complexes (IC) …

The activation, proliferation, differentiation, and trafficking of CD4 T cells is central to the
development of type I immune responses. MHC class II (MHCII)-bearing dendritic cells …

Langerhans cells have been thought to play a major role as APCs for induction of specific
immune responses to Leishmania major. Although their requirement for control of infection …

Professional antigen-presenting cells (APC) are able to process and present exogenous
antigen leading to the activation of T cells. Antigen–immunoglobulin (Ig) G complexes (IC) …