Engineered CpG‐antigen conjugates protected gold nanoclusters as smart self‐vaccines for enhanced immune response and cell imaging

Y Tao, E Ju, Z Li, J Ren, X Qu - Advanced Functional Materials, 2014 - Wiley Online Library
A facile one‐pot synthesis of fluorescent AuNCs by using ovalbumin‐CpG
oligodeoxynucleotides (ODNs) conjugates as the templates, which can elicit specific …

Preparation of surfactant-stabilized gold nanoparticle–peptide nucleic acid conjugates

J Duy, LB Connell, W Eck, SD Collins… - Journal of Nanoparticle …, 2010 - Springer
A simple, two-step method of producing stable and functional peptide nucleic acid (PNA)-
conjugated gold nanoparticles using a surfactant stabilization step is presented. PNA are …

Tumor targeting by peptide-decorated gold nanoparticles

B Albertini, V Mathieu, N Iraci… - Molecular …, 2019 - ACS Publications
Cancer remains one of the most important challenges in biomedical sciences.
Chemotherapeutic agents are very potent molecules that exhibit a significant level of toxicity …

One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model

A Rai, S Pinto, TR Velho, AF Ferreira, C Moita… - Biomaterials, 2016 - Elsevier
The increase in antibiotic drug resistance and the low number of new antibacterial drugs
approved in the last few decades requires the development of new antimicrobial strategies …

Quantification and reactivity of functional groups in the ligand shell of PEGylated gold nanoparticles via a fluorescence-based assay

L Maus, JP Spatz, R Fiammengo - Langmuir, 2009 - ACS Publications
We present a fluorescence-based assay for the characterization of functionalized gold
nanoparticles (AuNPs) capped with a self-assembled monolayer of mixed thiols derived …

Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells

D Mandal, A Maran, MJ Yaszemski… - Journal of Materials …, 2009 - Springer
Nanoparticles have been extensively used for a variety of biomedical applications and there
is a growing need for highly specific and efficient delivery of the nanoparticles into target …

The cellular interactions of PEGylated gold nanoparticles: effect of PEGylation on cellular uptake and cytotoxicity

SJ Soenen, BB Manshian… - Particle & Particle …, 2014 - Wiley Online Library
Poly (ethylene glycol)(PEG) is frequently used to coat various medical nanoparticles (NPs).
As PEG is known to minimize NP interactions with biological specimens, the question …

Controlled delivery of single or multiple antigens in tolerogenic nanoparticles using peptide-polymer bioconjugates

RM Pearson, LM Casey, KR Hughes, LZ Wang… - Molecular Therapy, 2017 - cell.com
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …

Methods of effective conjugation of antigens to nanoparticles as non-inflammatory vaccine carriers

SD Xiang, K Wilson, S Day, M Fuchsberger… - Methods, 2013 - Elsevier
It has recently become clear that nanoparticle size is a major determinant for how antigen
presenting cells (APCs), and specifically dendritic cells (DC) recognize and handle particles …

Pulmonary delivery of cationic gold nanoparticles boost antigen-specific CD4+ T cell proliferation

E Seydoux, L Rodriguez-Lorenzo, RAM Blom… - … , Biology and Medicine, 2016 - Elsevier
To address how surface charge affects the fate of potential nanocarriers in the lung, gold
nanoparticles (AuNPs) coated with polyvinyl alcohol containing either positively (NH 2) or …