Our knowledge of the mechanism of lymphocyte activation and proliferation by interleukin-2
(IL-2) and interleukin-2 receptor (IL-2-R) has expanded rapidly since the cloning of the …

Human T-cell leukemia virus (HTLV)-infected cell lines derived from adult T-cell leukemia
(ATL) express constitutively the receptor for Interleukin-2 (IL-2-R) and the associated antigen …

Late-phase human T-cell lymphotropic virus I-associated adult T-cell leukemia cells express
IL-2 receptors (IL-2R) but no longer produce IL-2. We have reported that the IL-2 …

In order to study the possible role of the T-lymphocyte growth factor, Interleukin 2 (IL-2),
and/or of the IL-2 receptor in the autonomous growth of leukaemic cells, 15 mouse …

A continuous cell line was established from the blood of a patient (HH) with an aggressive
cutaneous T‐cell leukemia/lymphoma who lacked antibodies to human T lymphotrophic …

Considerable advances in our understanding of the extracellular control of T-lytnphocyte
proliferation have been tnade in recent years. The characterization of the principal growth …

To evaluate the effect of IL‐4 on the growth of leukemic cells from adult T‐cell leukemia
(ATL) patients (ATL cells) and determine whether the IL‐4 autocrine mechanism is involved …

The accessory function for T cell activation and the production of interleukin 1 (IL 1) of adult
T cell leukemia (ATL) cell lines were studied in vitro. ATL cell lines such as Hut-102, MT-1 …

The proliferative response of fresh peripheral blood leukemic cells from eight adult T cell
leukemia (ATL) patients to interleukin-4 (IL-4) was studied to determine the possibility that …

The discovery and molecular characterization of interleukin-2 (IL-2) has had a considerable
impact on basic and clinical immunology (Morgan et al., 1976; Taniguchi et al., 1963; …