Context The optimal levothyroxine (LT4) dose to treat congenital hypothyroidism (CH)
remains unclear, with debate over whether higher starting doses (> 10 µg/kg) are necessary …

OBJECTIVES: To compare neurodevelopmental outcomes in severe and moderate
congenital hypothyroidism (CH) among 3 different initial L-thyroxine doses and to examine …

Objective: To determine between timing and LT4 dose which was the more important factor
for IQ at 7 years in screened congenital hypothyroidism (CH). Methods: 131 children with CH …

Background and aims: The optimal dose of thyroxine (T4) in congenital hypothyroidism (CH)
during infancy is controversial. Higher doses lead to improvement in cognitive scores, but …

Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal
or near-normal neurocognitive outcome in infants with congenital hypothyroidism. Many …

The appropriateness of the recommended L-thyroxine dose (10-15 μg/kg/day) for the
treatment of congenital hypothyroidism has been questioned because of the risk of …

Background: Current guidelines recommend an initial L-thyroxine (L-T4) dose of 10–15
μg/kg/day for the treatment of congenital hypothyroidism (CH). We analyzed our data for the …

Purpose Delayed treatment of congenital hypothyroidism (CH) is a common cause of mental
retardation. The aim of the present study was to evaluate intellectual outcomes in preschool …

To evaluate the effect of different initial levothyroxine (LT4) replacement doses on growth
and intellectual outcome in patients with congenital hypothyroidism (CH) detected by …

Neonatal thyroid screening programs were first im-plemented in the mid-to late 1970s to
detect congenital hypothyroidism (CH) as soon after birth as possible and begin therapy …