The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells,
that when expressed, have the potential to be tumor-specific immune targets. Neoantigen …

Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …

Cancer immunotherapy has achieved multiple clinical benefits and has become an
indispensable component of cancer treatment. Targeting tumor-specific antigens, also …

Neoantigens are tumor-specific proteins and peptides that can be highly immunogenic.
Immune-mediated tumor rejection is strongly associated with cytotoxic responses to …

Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …

During their development and progression tumors acquire numerous mutations that, when
translated into proteins give rise to neoantigens that can be recognized by T cells. Initially …

Personal neoantigen–based cancer vaccines are designed to target antigens arising from
tumor-specific mutations within individual cancers and present a tremendous opportunity to …

Tumor neoantigens possess specific immunogenicity and personalized therapeutic vaccines
based on neoantigens which have shown promising results in some clinical trials, with …