Antimicrobial activity of human β-defensin 4 analogs: insights into the role of disulfide linkages in modulating activity
Human β-defensins (HBDs) are cationic antimicrobial peptides that are components of the
innate immune system. They are characterized by three disulfide bridges. However, the …
innate immune system. They are characterized by three disulfide bridges. However, the …
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
O Scudiero, S Galdiero, M Cantisani… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …
Structure− activity relation of human β-defensin 3: influence of disulfide bonds and cysteine substitution on antimicrobial activity and cytotoxicity
E Klüver, S Schulz-Maronde, S Scheid, B Meyer… - Biochemistry, 2005 - ACS Publications
Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
Antimicrobial characterization of human β-defensin 3 derivatives
DM Hoover, Z Wu, K Tucker, W Lu… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
Identification of structural traits that increase the antimicrobial activity of a chimeric peptide of human β-defensins 2 and 3
B Spudy, FD Sönnichsen, GH Waetzig… - Biochemical and …, 2012 - Elsevier
Antimicrobial peptides participate in the first line of defence of many organisms against
pathogens. In humans, the family of β-defensins plays a pivotal role in innate immunity. Two …
pathogens. In humans, the family of β-defensins plays a pivotal role in innate immunity. Two …
Antibacterial activities of synthetic peptides corresponding to the carboxy-terminal region of human β-defensins 1–3
The antibacterial activities of synthetic human β-defensin analogs, constrained by a single
disulfide bridge and in the reduced form, have been investigated. The peptides span the …
disulfide bridge and in the reduced form, have been investigated. The peptides span the …
Structural and functional characterization of hBD-1 (Ser35), a peptide deduced from a DEFB1 polymorphism
β-Defensins are mammalian antimicrobial peptides that share a unique disulfide-bonding
motif of six conserved cysteines. An intragenic polymorphism of the DEFB1 gene that …
motif of six conserved cysteines. An intragenic polymorphism of the DEFB1 gene that …
Engineering of a linear inactive analog of human β‐defensin 4 to generate peptides with potent antimicrobial activity
Human β‐defensins (HBDs) are cationic antimicrobial peptides constrained by three
disulfide bridges. They have diverse range of functions in the innate immune response. It is …
disulfide bridges. They have diverse range of functions in the innate immune response. It is …
A study of host defence peptide β-defensin 3 in primates
M Boniotto, N Antcheva, I Zelezetsky, A Tossi… - Biochemical …, 2003 - portlandpress.com
We have investigated the molecular evolution of the gene coding for β-defensin 3
(DEFB103) in 17 primate species including humans. Unlike the DEFB4 genes (coding for β …
(DEFB103) in 17 primate species including humans. Unlike the DEFB4 genes (coding for β …
Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines
Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are
thus prime candidates as therapeutic agents directed against infective diseases. Based on …
thus prime candidates as therapeutic agents directed against infective diseases. Based on …
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