Human β-defensins (HBDs) are cationic antimicrobial peptides that are components of the
innate immune system. They are characterized by three disulfide bridges. However, the …

Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …

Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …

ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …

Antimicrobial peptides participate in the first line of defence of many organisms against
pathogens. In humans, the family of β-defensins plays a pivotal role in innate immunity. Two …

The antibacterial activities of synthetic human β-defensin analogs, constrained by a single
disulfide bridge and in the reduced form, have been investigated. The peptides span the …

β-Defensins are mammalian antimicrobial peptides that share a unique disulfide-bonding
motif of six conserved cysteines. An intragenic polymorphism of the DEFB1 gene that …

Human β‐defensins (HBDs) are cationic antimicrobial peptides constrained by three
disulfide bridges. They have diverse range of functions in the innate immune response. It is …

We have investigated the molecular evolution of the gene coding for β-defensin 3
(DEFB103) in 17 primate species including humans. Unlike the DEFB4 genes (coding for β …

Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are
thus prime candidates as therapeutic agents directed against infective diseases. Based on …