In yeast, the major mRNA degradation pathway is initiated by poly (A) tail shortening that
triggers mRNA decapping. The mRNA is then degraded by 5′-to-3′ exonucleolysis. In …

The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

Rapid degradation of many labile mRNAs is regulated in part by an A+ U-rich element (ARE)
in their 3′-untranslated regions. Extensive mutational analyses of various AREs have …

The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the
B'untranslated region. We introduced a 51 nucleotide AT sequence from a human …

We have identified a cellular target for proteasomal endonuclease activity. Thus, 20 S
proteasomes interact with the 3′-untranslated region of certain cytoplasmic mRNAs in vivo …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …

AU-rich elements (AREs), located in the 3′-untranslated region of unstable cytokine and
chemokine mRNAs, promote rapid decay of otherwise stable mRNAs and may mediate …

The stability of several oncogene, cytokine, and growth factor transcripts is tightly regulated
by signaling pathways through an ARE (AU-rich element) present in their 3′-UTRs. We …

Poly (A) tails are important elements in mRNA translation and stability, although recent
genome-wide studies have concluded that poly (A) tail length is generally not associated …