The addition of poly (A)-tails to RNA is a process common to almost all organisms. In
eukaryotes, stable poly (A)-tails, important for mRNA stability and translation initiation, are …

In monocyte/macrophages, the translation of tumor necrosis factor α (TNF-α) mRNA is tightly
regulated. In unstimulated cells, translation of TNF-α mRNA is blocked. Upon stimulation …

In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Eukaryotic mRNAs can be degraded in either decapping/5′-to-3′ or 3′-to-5′ direction
after deadenylation. In yeast and mammalian cells, decay factors involved in the 5′-to-3 …

An important control point in gene expression is at the level of messenger RNA (mRNA)
stability. The mRNAs of certain regulatory cellular proteins such as oncogenes, cytokines …

AU-rich elements within the 3'untranslated region of transcripts of lymphokines and some
protooncogenes serve as signal for rapid mRNA degradation. By using an AUUUA matrix …

An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

The addition of poly (A) tails to eukaryotic nuclear mRNAs promotes their stability, export to
the cytoplasm and translation. Subsequently, the balance between exonucleolytic …

Post-transcriptional pathways provide a major means of regulating eukaryotic gene
expression. Reiterations of the AU-rich element (ARE) within the 3′-untranslated region of …

The A+ U-rich elements (or AREs) are cis-acting sequences that activate rapid mRNA decay,
yet the overall polarity of this process is unknown. The current study describes an unbiased …