The cytoplasmic metabolism of two adenovirus (Ad2)-specific messenger RNAs, encoded
within the left-hand 11% of the Ad2 genome, has been examined in a transformed rat …

In mammalian cells, the enzymatic pathways involved in cytoplasmic mRNA decay are
incompletely defined. In this study, we have used two approaches to disrupt activities of …

AU-rich elements (ARE) present in the 3′ untranslated regions of many cytokines and
immediate-early genes are responsible for targeting the transcripts for rapid decay. We …

Polyadenylation is an essential step for the maturation of almost all cellular mRNAs in
eukaryotes. In human cells, most poly (A) sites are flanked by the upstream AAUAAA …

The highly unstable c-myc mRNA has been shown to be stabilized in cells treated with
protein synthesis inhibitors. We have studied this phenomenon in an effort to gain more …

The AU-rich element (ARE) in the 3′ untranslated region of unstable mRNAs mediate their
rapid degradation. ARE binding proteins (AUBPs) have been described that either stabilize …

AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding
many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a …

The human U1A protein‐U1A pre‐mRNA complex and the relationship between its structure
and function in inhibition of polyadenylation in vitro were investigated. Two molecules of …

HT1080 cells stably expressing green fluorescent protein (GFP) linked to a 3′ terminal AU‐
rich element (ARE) proved to be a convenient system to study the dynamics of mRNA …

The 3′ UTRs of mammalian HIF-1α and EGF mRNA contain several highly conserved AU-
rich elements (ARE) known to control the turnover of labile mRNAs by binding ARE-binding …