Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …

To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …

The first step in the decay of some eukaryotic mRNAs is the shortening of the poly (A) tail. To
examine how the transcript body was degraded after deadenylation, we followed the decay …

INTRODUCTION The polyadenylate [poly (A)] tail is one of the most conserved modifications
of RNA molecules and is an important contributor to RNA function. In conjunction with other …

The addition of a poly (A) tail has been examined in a HeLa cell nuclear extract using SV40
late RNAs that end at or near the natural poly (A) site. We find that the addition of a full …

Most eukaryotic mRNAs have a poly (A) tail added onto their 3'ends, probably as an early
step in the maturation of the primary transcript. This process involves both cleavage of the …

The cationic amino acid transporter, Cat-1, is a high affinity transporter of the essential
amino acids, arginine and lysine. Expression of the cat-1 gene increases during nutritional …

Abstract (A+ U)-rich elements (AREs) within 3′ untranslated regions are signals for rapid
degradation of messenger RNAs encoding many oncoproteins and cytokines. The ARE …

Inherently unstable mRNAs contain AU-rich elements (AREs) in their 3′ untranslated
regions that act as mRNA stability determinants by interacting with ARE-binding proteins …

Translation of poly (A) tails leads to mRNA cleavage but the mechanism and global
pervasiveness of this “nonstop/no-go” decay process is not understood. Here we performed …