Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential
Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or …
program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or …
[HTML][HTML] Serum leptin is not altered nor related to cognitive decline in Alzheimer's disease
CE Teunissen, WM van der Flier… - Journal of …, 2015 - content.iospress.com
Background: Low plasma leptin levels can be a risk factor for Alzheimer's disease (AD) but
the relation of leptin with disease progression in clinical AD is unknown. Objective: The aim …
the relation of leptin with disease progression in clinical AD is unknown. Objective: The aim …
Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment
R Oania, LK McEvoy - Age and ageing, 2014 - academic.oup.com
Background: animal studies suggest a neuroprotective role for leptin, but human studies
have shown mixed results. We examined whether plasma leptin levels in individuals with …
have shown mixed results. We examined whether plasma leptin levels in individuals with …
Plasma leptin is associated with amyloid CSF biomarkers and Alzheimer's disease diagnosis in cognitively impaired patients
M Lilamand, E Bouaziz-Amar… - The Journals of …, 2023 - academic.oup.com
Background Metabolic dysfunction and dysregulation of leptin signaling have been linked to
Alzheimer's disease (AD)'s pathophysiology. The objectives of this study were to examine …
Alzheimer's disease (AD)'s pathophysiology. The objectives of this study were to examine …
Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
Context The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the
hippocampus, promotes β-amyloid clearance, and improves memory function in animal …
hippocampus, promotes β-amyloid clearance, and improves memory function in animal …
Association between leptin, cognition, and structural brain measures among “early” middle-aged adults: results from the Framingham Heart Study third generation …
V Sanborn, SR Preis, A Ang, S Devine… - Journal of …, 2020 - content.iospress.com
Background: There is growing interest in the pathophysiological processes of preclinical
Alzheimer's disease (AD), including the potential role of leptin. Human studies have shown …
Alzheimer's disease (AD), including the potential role of leptin. Human studies have shown …
Effects of gender and other confounding factors on leptin concentrations in Alzheimer's disease: evidence from the combined analysis of 27 case-control studies
F Zhou, S Chen - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Leptin, as a link between fat mass and the brain, has been reported to be associated with
gender. The gender differences in leptin levels between Alzheimer's disease (AD) and …
gender. The gender differences in leptin levels between Alzheimer's disease (AD) and …
Leptin: the missing link in Alzheimer disease?
J Harvey - Clinical chemistry, 2010 - academic.oup.com
In Western societies, life expectancy is increasing steadily. As a consequence, more
individuals are suffering from age-related disorders such as Alzheimer disease (AD). 2 The …
individuals are suffering from age-related disorders such as Alzheimer disease (AD). 2 The …
Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults
S Lee, MS Byun, D Yi, H Ahn, G Jung… - JAMA network …, 2024 - jamanetwork.com
Importance Many epidemiologic studies have suggested that low levels of plasma leptin, a
major adipokine, are associated with increased risk of Alzheimer disease (AD) dementia …
major adipokine, are associated with increased risk of Alzheimer disease (AD) dementia …
Circulating leptin levels and weight loss in Alzheimer's disease patients
DA Power, J Noel, R Collins, D O'Neill - Dementia and geriatric …, 2001 - karger.com
Weight loss is common in Alzheimer's disease (AD) and is predictive of mortality. Leptin, an
adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy …
adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy …