[HTML][HTML] Gelsevirine is a novel STING-specific inhibitor and mitigates STING-related inflammation in sepsis
Y Chen, H Bian, J Lv, W Song, C Xing, C Hui… - Frontiers in …, 2023 - frontiersin.org
Background Stimulation of IFN genes (STING) is central to the production of interferon and
proinflammatory cytokines in response to microbial DNA or self-DNA in the cytosol. The …
proinflammatory cytokines in response to microbial DNA or self-DNA in the cytosol. The …
STING, a promising target for small molecular immune modulator: A review
Y Liu, X Lu, N Qin, Y Qiao, S Xing, W Liu, F Feng… - European Journal of …, 2021 - Elsevier
Stimulator of interferon genes (STING) plays a crucial role in human innate immune system,
which is gradually concerned following the emerging immunotherapy. Activated STING …
which is gradually concerned following the emerging immunotherapy. Activated STING …
[HTML][HTML] STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis
ZZ Liu, YJ Yang, CK Zhou, SQ Yan, K Ma… - Frontiers in …, 2021 - frontiersin.org
STING (Stimulator of interferon genes) is known as an important adaptor protein or direct
sensor in the detection of nucleotide originating from pathogens or the host. The implication …
sensor in the detection of nucleotide originating from pathogens or the host. The implication …
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor
NN Chen, H Zhang, QS Zhu, T Zeng… - Journal of Medicinal …, 2023 - ACS Publications
Stimulator of interferon gene (STING) is a critical adaptor protein that has a pivotal role in
triggering inherent immune responses to infection. STING-linked interferon production has …
triggering inherent immune responses to infection. STING-linked interferon production has …
Targeting stimulator of interferon genes (STING): a medicinal chemistry perspective
H Zhang, QD You, XL Xu - Journal of medicinal chemistry, 2019 - ACS Publications
Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of
type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of …
type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of …
[HTML][HTML] IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities
X He, A Wedn, J Wang, Y Gu, H Liu, J Zhang… - Pharmacological …, 2024 - Elsevier
Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms
Stimulator of interferon genes (STING), as a signaling hub in innate immunity, plays a central
role for the effective initiation of host defense mechanisms against microbial infections. Upon …
role for the effective initiation of host defense mechanisms against microbial infections. Upon …
[HTML][HTML] Activation of STING based on its structural features
B Hussain, Y Xie, U Jabeen, D Lu, B Yang… - Frontiers in …, 2022 - frontiersin.org
The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade
responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a …
responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a …
[HTML][HTML] Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
[HTML][HTML] Post-translational modifications of STING: a potential therapeutic target
J Kang, J Wu, Q Liu, X Wu, Y Zhao, J Ren - Frontiers in Immunology, 2022 - frontiersin.org
Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …
essential roles in immune responses against microbial infections. However, over-activation …