[HTML][HTML] In vitro evaluation, in silico studies and toxicological assay of some xanthones as potential Leishmania donovani inhibitors

MS Osman, SW Shantier, TA Awad… - Informatics in Medicine …, 2022 - Elsevier
Xanthones are naturally occurring compounds that exist in some higher plants, fungi and
lichen. Natural and synthetic xanthones have shown diverse biological and pharmacological …

[PDF][PDF] In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection. Biology 2022, 11, 133

A Vicente-Barrueco, ÁC Román, T Ruiz-Téllez… - 2022 - academia.edu
Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To
advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical …

Insights into the molecular basis of some chalcone analogues as potential inhibitors of Leishmania donovani: An integrated in silico and in vitro study

MS Osman, TA Awad, SW Shantier, EAE Garelnabi… - Open …, 2022 - degruyter.com
Protozoal infections caused by species belonging to Leishmania donovani complex are
responsible for the most severe form of leishmaniasis, especially in Sudan and other …

[HTML][HTML] Synthesis and biological evaluation of 9-aryl-1, 8-dioxo-octahydroxanthene derivatives as antileishmanial agents

K Lodha, D Wavhal, N Bhujbal, P Mazire, S Bhujbal… - Results in …, 2023 - Elsevier
In the current research, we designed and synthesized various derivatives of 9-aryl-1, 8-dioxo-
octahydroxanthene using flow chemistry technique and explored in vitro study for …

In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection

A Vicente-Barrueco, ÁC Román, T Ruiz-Téllez… - Biology, 2022 - mdpi.com
Simple Summary In this work, we show bioinformatic procedures to search for new drugs
form plant-derived molecules, previously described in ethnobotany as useful for the …

Molecular modeling studies of benzimidazolyl-chalcones as antileishmanial agents using qsar, docking, ADME and molecular dynamics studies

DUJP N'guessan, AA Alzain, EM Adouko… - Journal of Applied …, 2021 - japsr.in
Introduction: Present leishmaniasis treatment regimen has many limitations including severe
adverse effects, toxicity, and Leishmania strains resistance. In the present study, the …

Coumarin analogues as a potential inhibitor of leishmaniasis: A multi-targeting protein inhibition approach by molecular docking

K Kapoor - Universal Journal of Pharmaceutical Research, 2019 - ujpronline.com
Objective: Leishmaniasis is one of the most dreadful diseases as a leading cause of death in
most of the developed countries. Objective of the current work was to identify more potent …

Identification of 3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors against Trypanothione Reductase from Leishmania Infantum Using …

S Maamri, K Benarous, M Yousfi - Molecules, 2021 - mdpi.com
Polyphenolic and Terpenoids are potent natural antiparasitic compounds. This study aimed
to identify new drug against Leishmania parasites, leishmaniasis's causal agent. A new in …

Computational studies on new Leishmanial drug targets against Quercetin

K Jyothi, V Sivaranjani, U Pavithra… - Indian Journal of …, 2022 - op.niscpr.res.in
Leishmaniasis, a parasitic disease caused by Leishmania parasite which resides in the
infected sand flies. Control of Leishmaniasis remains a source of grave concern worldwide …

2,3-Dihydroquinazolin-4(1H)-one as a New Class of Anti-Leishmanial Agents: A Combined Experimental and Computational Study

M Sarfraz, C Wang, N Sultana, H Ellahi, MF Rehman… - Crystals, 2021 - mdpi.com
Leishmaniasis is a neglected parasitic disease caused by various Leishmania species. The
discovery of new protozoa drugs makes it easier to treat the disease; but, conventional …