Abstract C D8 T-cell responses play an important role in protection against intracellular
pathogens. Memory CD8 T cells mediate rapid clearance of pathogens upon secondary …

Clearance of primary infection often leads to the development of highly functional memory T
cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections …

Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore
it is imperative to define the parameters that regulate the development and preservation of …

Viral infections often induce potent CD8 T cell responses that play a key role in antiviral
immunity. After viral clearance, the vast majority of the expanded CD8 T cells undergo …

Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

CD8 T cells contribute to clearance and long-term protection following acute infection with
certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity …

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the
dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …