The diseases of critical illness are rooted in the response of the host to clinical interventions
that have thwarted imminent death. Sepsis—the clinical syndrome that embodies the …

Pathophysiologic basis of sepsis: Considerations for future... : Critical Care Medicine
Pathophysiologic basis of sepsis: Considerations for future strategies of intervention : Critical …

Sepsis, the life-threatening illness that arises from innate immunity to overwhelming
infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years …

Infectious disease has been a leading cause of death in humans since the first recorded
tabulations. From Hippocrates and Galen, to Lister, Fleming and Semmelweiss, this article …

This textbook is written at the dawn of a new era in the management of sepsis. Recent
achievements in the clinical management of septic shock are the culmination of decades of …

Sepsis is the major cause of death in non-cardiologic intensive care units around the world.
Every year, billions of dollars are consumed in the treatment of sepsis and in research to …

Sepsis, defined as an infection accompanied by inflammation, is a complex disease process
wherein the body's response to a pathogen is amplified far beyond the initial site of infection …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Sepsis is a clinical syndrome defined by a systemic response to infection. With progression
to sepsis-associated organ failure (ie, severe sepsis) or hypotension (ie, septic shock) …

Homo sapiens (literally meaning ''wise man'') and immediate prehominid ancestors have
been at risk of death from infection since first descending from the trees (about 3 million …