Microglial polarization is one of the most promising therapeutic strategies for multiple central
nervous system (CNS) disorders. However, safe, effective, and controllable microglial …

Background Ischemic stroke is one of the most serious global public health problems.
However, the performance of current therapeutic regimens is limited due to their poor target …

Oxidative stress and a series of excessive inflammatory responses are major obstacles for
neurological functional recovery after ischemic stroke. Effective noninvasive anti …

Stroke is the most common cause of disability globally. Neural stem cell (NSC) therapy,
which can replace lost and damaged neurons, has been proposed as a potential treatment …

Stroke is followed by an intricate immune interaction involving the engagement of multiple
immune cells, including neutrophils. As one of the first responders recruited to the brain, the …

Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As
such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After …

Cerebral ischemic injury is an important factor affecting the prognosis of acute ischemic
stroke (AIS). Neuronal apoptosis and the change in microglial phenotype have been …

focuses on the inflammatory response after stroke and other inflammatory diseases at the
onset to prevent secondary injuries that result in poor outcomes. Our aim was to collect the …

Microglia are important cells that act on regulating neuroinflammation and neurofunction
after the induction of ischemic stroke (IS). Consequently, the efficient accumulation of drugs …

High potency and safe therapies are still required for ischemic stroke, which is a leading
cause of global death and disability. Herein, a reactive oxygen species (ROS)-responsive …