Tumor progression to the invasive phenotype occurs secondary to upregulated signaling
from growth factor receptors that drive key cellular responses like proliferation, migration …

PURPOSE: The development of effective, novel, targeted cancer therapies with minimal side
effects has long been a goal in cancer research. A key group of targets identified for drug …

Despite multiple reports of overexpression in prostate cancer (PC), the reliance of PC cells
on activated epidermal growth factor receptor (EGFR) and its downstream signaling to …

The primary focus of this investigation was to study the relationship between
neuroendocrine (NE) differentiation, epidermal growth factor (EGF) because both have been …

The molecular mechanisms of prostate cancer are still poorly understood, despite the threat
that prostate cancer poses to the health of men worldwide. As prostate tumors are initially …

Abstract Background The CXCL12/CXCR4 axis transactivates HER2 and promotes
intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we …

The epidermal growth factor receptor (EGFR) plays an important role in the development
and progression of prostate cancer and its overexpression is associated with decreased …

Abstract Background Prostate cancer (PCa) remains a challenge worldwide. Due to the
development of castration-resistance, traditional first-line androgen deprivation therapy …

Although androgens and the androgen receptor (AR) are involved in tumorigenesis of
prostate cancer (PC) in initial phases, less clear is the role played in advanced androgen …

Abstract Background Metastatic Prostate cancer (PCa) cells have gained survival and
invasive advantages. Epidermal growth factor (EGF) receptor is a receptor tyrosine kinase …