Background and objectives Many patients with epilepsy are treated with antiepileptic drug
(AED) polytherapy. Several factors influence the choice of early add-on therapy, and …

Purpose To evaluate the 1-year efficacy and safety of oral lacosamide as conversion
monotherapy in adult patients with partial onset seizures with or without generalization …

Rationale Many patients with epilepsy need a second antiepileptic drug (AED), due either to
inefficacy or side effects of the first tried one. We evaluated the efficacy and safety of …

Lacosamide is approved as adjunctive therapy for focal epilepsies. The number of
antiepileptic drugs (AEDs) tried is associated with prognosis. This multicenter, retrospective …

Objective To evaluate long‐term (up to 5.5 years) safety, seizure reduction, and
maintenance of efficacy of the antiepileptic drug (AED) lacosamide as adjunctive treatment …

Long-term (up to 8 years of exposure) safety and efficacy of the antiepileptic drug
lacosamide was evaluated in this open-label extension trial (SP615 [ClinicalTrials. gov …

Purpose: To evaluate the long‐term (up to 5 years exposure) safety and efficacy of
lacosamide as adjunctive therapy in patients with uncontrolled partial‐onset seizures taking …

Purpose To evaluate the efficacy and safety of lacosamide administered as either first add-
on or later add-on antiepileptic drug (AED) therapy for patients with uncontrolled partial …

Objective Evidence for the efficacy and safety of adjunctive lacosamide in the treatment of
partial‐onset seizures (POS) was gained during placebo‐controlled clinical trials in patients …

Purpose: To examine the safety and tolerability of rapidly initiating adjunctive lacosamide via
a single intravenous loading dose followed by twice‐daily oral lacosamide in lacosamide …