Deceased donor kidney function is determined by branch chained amino acid metabolism during ex vivo normothermic perfusion
A Ahmadi, JMU Yu, JE Loza, BC Howard, I Palma… - medRxiv, 2023 - medrxiv.org
Current kidney perfusion protocols are not optimized for addressing the ex vivo
physiological and metabolic needs of the kidney. Ex vivo normothermic perfusion (EVNP) …
physiological and metabolic needs of the kidney. Ex vivo normothermic perfusion (EVNP) …
Combined ex vivo hypothermic and normothermic perfusion for assessment of high-risk deceased donor human kidneys for transplantation
SK Kabagambe, IP Palma, Y Smolin, T Boyer… - …, 2019 - journals.lww.com
Background Despite careful clinical examination, procurement biopsy and assessment on
hypothermic machine perfusion, a significant number of potentially useable deceased donor …
hypothermic machine perfusion, a significant number of potentially useable deceased donor …
The Impact of Nutritional Supplementation on Donor Kidneys During Oxygenated Ex Vivo Subnormothermic Preservation
RN Bhattacharjee, A Jackson… - Transplantation …, 2022 - journals.lww.com
Background. Evidence suggests that nutritional supplementation during normothermic ex
vivo perfusion improves organ preservation. However, it is unclear whether the same benefit …
vivo perfusion improves organ preservation. However, it is unclear whether the same benefit …
Normothermic kidney preservation
A Weissenbacher - 2018 - ora.ox.ac.uk
The thesis describes the development of a transportable normothermic kidney preservation
device which is able to perfuse discarded human and porcine kidneys for up to 24 hours for …
device which is able to perfuse discarded human and porcine kidneys for up to 24 hours for …
Developing a safe 15-hour preservation protocol of donor kidneys using normothermic machine perfusion
J Stone, W Cowey, C Bowers, A Stewart, E Armstrong… - bioRxiv, 2023 - biorxiv.org
Introduction Background: Normothermic machine perfusion (NMP) offers a superior
alternative to existing hypothermic preservation strategies but is currently limited to 1-3 …
alternative to existing hypothermic preservation strategies but is currently limited to 1-3 …
[HTML][HTML] Subnormothermic oxygenated perfusion optimally preserves donor kidneys ex vivo
RN Bhattacharjee, A Ruthirakanthan, Q Sun… - Kidney International …, 2019 - Elsevier
Introduction The current methods of preserving donor kidneys in nonoxygenated cold
conditions minimally protect the kidney against ischemia-reperfusion injury (IRI), a major …
conditions minimally protect the kidney against ischemia-reperfusion injury (IRI), a major …
An assessment of urinary biomarkers in a series of declined human kidneys measured during ex vivo normothermic kidney perfusion
SA Hosgood, ML Nicholson - Transplantation, 2017 - journals.lww.com
Background The measurement of urinary biomarkers during ex vivo normothermic kidney
perfusion (EVKP) may aid in the assessment of a kidney prior to transplantation. This study …
perfusion (EVKP) may aid in the assessment of a kidney prior to transplantation. This study …
[HTML][HTML] Hemodynamics and metabolic parameters in normothermic kidney preservation are linked with donor factors, perfusate cells, and cytokines
A Weissenbacher, JP Stone, ML Lo Faro… - Frontiers in …, 2022 - frontiersin.org
Kidney transplantation is the best renal-replacement option for most patients with end-stage
renal disease. Normothermic machine preservation (NMP) of the kidney has been studied …
renal disease. Normothermic machine preservation (NMP) of the kidney has been studied …
Current insights into the metabolome during hypothermic isolated kidney perfusion–A scoping review.
L Verstraeten, I Jochmans - 2022 - osf.io
Kidney transplantation is the treatment of choice for patients with end-stage renal disease as
it improves quality of life and reduces mortality when compared to long-term dialysis (1) …
it improves quality of life and reduces mortality when compared to long-term dialysis (1) …
213.6: Expanding the boundaries of functional warm ischemia time (fWIT): successful kidney transplantation using normothermic machine perfusion (nmp) of a …
D Choudhary, S Singh, SP Shivkumar… - …, 2023 - journals.lww.com
Methods: This report details the successful transplantation of a discarded kidney due to fWIT
of 7 hrs from a 23-year-male donor with acute kidney injury (serum creatinine sCr-5.06 …
of 7 hrs from a 23-year-male donor with acute kidney injury (serum creatinine sCr-5.06 …