Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
RT Graser, TP DiLorenzo, F Wang… - The Journal of …, 2000 - journals.aai.org
Previous work has indicated that an important component for the initiation of autoimmune
insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I …
insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I …
Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice
S You, G Slehoffer, S Barriot, JF Bach… - Proceedings of the …, 2004 - National Acad Sciences
Converging experimental evidence indicates that CD4+ regulatory T cells control
progression of autoimmune insulitis in nonobese diabetic (NOD) mice. Here, we studied the …
progression of autoimmune insulitis in nonobese diabetic (NOD) mice. Here, we studied the …
Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a …
TP DiLorenzo, RT Graser, T Ono… - Proceedings of the …, 1998 - National Acad Sciences
Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to
autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major …
autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major …
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice
J Verdaguer, D Schmidt, A Amrani… - The Journal of …, 1997 - rupress.org
It has been established that insulin-dependent diabetes mellitus (IDDM) in nonobese
diabetic (NOD) mice results from a CD4+ and CD8+ T cell–dependent autoimmune process …
diabetic (NOD) mice results from a CD4+ and CD8+ T cell–dependent autoimmune process …
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice
C Mora, FS Wong, CH Chang… - The Journal of …, 1999 - journals.aai.org
The NOD (nonobese diabetic) mouse is a good animal model for human IDDM. MHC class II-
restricted CD4 T cells are necessary for the onset of diabetes in NOD mice. Here, we …
restricted CD4 T cells are necessary for the onset of diabetes in NOD mice. Here, we …
β cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice
J De Jersey, SL Snelgrove, SE Palmer… - Proceedings of the …, 2007 - National Acad Sciences
Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet β cells. CD8 T
cells are prevalent in the islets of T1D patients and are the major effectors of β cell …
cells are prevalent in the islets of T1D patients and are the major effectors of β cell …
The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice
TP DiLorenzo, DV Serreze - Immunological reviews, 2005 - Wiley Online Library
Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is a T‐cell‐
mediated autoimmune disease in which the insulin‐producing pancreatic islet β‐cells are …
mediated autoimmune disease in which the insulin‐producing pancreatic islet β‐cells are …
[HTML][HTML] Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations
JM Phillips, NM Parish, T Raine, C Bland… - The review of diabetic …, 2009 - ncbi.nlm.nih.gov
Type 1 diabetes development in NOD mice appears to require both CD4+ and CD8+ T cells.
However, there are some situations where it has been suggested that either CD4+ or CD8+ …
However, there are some situations where it has been suggested that either CD4+ or CD8+ …
A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice
HS Han, HS Jun, T Utsugi, JW Yoon - Journal of Autoimmunity, 1996 - Elsevier
Insulin-dependent diabetes mellitus (IDDM) in the non-obese diabetic (NOD) mouse results
from effector T cell-mediated autoimmune processes directed against pancreatic beta cells …
from effector T cell-mediated autoimmune processes directed against pancreatic beta cells …
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes
S Lesage, SB Hartley, S Akkaraju, J Wilson… - The Journal of …, 2002 - rupress.org
Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in
human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited …
human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited …
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