Genome-wide association studies
A Dehghan - Genetic Epidemiology: Methods and Protocols, 2018 - Springer
Genetic association studies have made a major contribution to our understanding of the
genetics of complex disorders over the last 10 years through genome-wide association …
genetics of complex disorders over the last 10 years through genome-wide association …
[HTML][HTML] Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
[HTML][HTML] Chapter 11: Genome-wide association studies
Genome-wide association studies (GWAS) have evolved over the last ten years into a
powerful tool for investigating the genetic architecture of human disease. In this work, we …
powerful tool for investigating the genetic architecture of human disease. In this work, we …
Genome-wide association studies: past, present and future
MI McCarthy, JN Hirschhorn - Human molecular genetics, 2008 - academic.oup.com
When the time came to decide on the topic for the next in the series of Human Molecular
Genetics reviews, on this occasion, there was little need for debate. The advent of genome …
Genetics reviews, on this occasion, there was little need for debate. The advent of genome …
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …
common genetic variants and phenotypes and numerous discoveries of new loci associated …
Genome-wide association studies: hypothesis-“free” or “engaged”?
GD Kitsios, E Zintzaras - Translational Research, 2009 - Elsevier
The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …
conceptual framework in the search for variants underlying common disorders: a massive …
Rare-variant studies to complement genome-wide association studies
A Sazonovs, JC Barrett - Annual review of genomics and human …, 2018 - annualreviews.org
Genome-wide association studies (GWASs) have revolutionized human disease genetics by
discovering tens of thousands of associations between common variants and complex …
discovering tens of thousands of associations between common variants and complex …
The positives, protocols, and perils of genome‐wide association
Genome‐wide association aims to comprehensively survey genetic variation for the
purposes of disease and trait mapping. We provide a brief history of the development of …
purposes of disease and trait mapping. We provide a brief history of the development of …
Genome-wide association studies in diverse populations
NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …
associated with disease phenotypes. As most GWA studies have been performed in …