Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies
K Siontis, NA Patsopoulos, J Ioannidis - European Journal of Human …, 2010 - nature.com
Genome-wide association studies (GWASs) have created a paradigm shift in discovering
genetic associations for common diseases and phenotypes, but it is unclear whether the …
genetic associations for common diseases and phenotypes, but it is unclear whether the …
Guidelines for genome-wide association studies
Genome-wide association studies (GWAS) have revolutionized human genetics. They have
led to the identification of thousands of loci that affect both normal variation and susceptibility …
led to the identification of thousands of loci that affect both normal variation and susceptibility …
Is replication the gold standard for validating genome-wide association findings?
With the advent of genome-wide association (GWA) studies, researchers are hoping that
reliable genetic association of common human complex diseases/traits can be detected …
reliable genetic association of common human complex diseases/traits can be detected …
Genome-wide association studies and beyond
JS Witte - Annual review of public health, 2010 - annualreviews.org
Genome-wide association studies (GWAS) provide an important avenue for undertaking an
agnostic evaluation of the association between common genetic variants and risk of …
agnostic evaluation of the association between common genetic variants and risk of …
Genome-wide association studies of quantitative traits with related individuals: little (power) lost but much to be gained
PM Visscher, T Andrew, DR Nyholt - European Journal of Human …, 2008 - nature.com
For complex disease genetics research in human populations, remarkable progress has
been made in recent times with the publication of a number of genome-wide association …
been made in recent times with the publication of a number of genome-wide association …
Five years of GWAS discovery
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …
experimental design of genome-wide association studies (GWASs). These studies were …
Rare variants create synthetic genome-wide associations
Genome-wide association studies (GWAS) have now identified at least 2,000 common
variants that appear associated with common diseases or related traits (http://www. genome …
variants that appear associated with common diseases or related traits (http://www. genome …
10 years of GWAS discovery: biology, function, and translation
Application of the experimental design of genome-wide association studies (GWASs) is now
10 years old (young), and here we review the remarkable range of discoveries it has …
10 years old (young), and here we review the remarkable range of discoveries it has …
What can genome-wide association studies tell us about the genetics of common disease?
MM Iles - PLoS genetics, 2008 - journals.plos.org
The success of genome-wide association studies relies on much of the risk of common
diseases being due to common genetic variants; but evidence for this is inconclusive. The …
diseases being due to common genetic variants; but evidence for this is inconclusive. The …
Collaborative Genome-Wide Association Studies of Diverse Diseases: Programs of the NHGRI's Office of Population Genomics
TA Manolio - Pharmacogenomics, 2009 - Taylor & Francis
In the past 3 years, genome-wide association (GWA) studies have revolutionized the
discovery of genetic variants associated with complex diseases. These studies present …
discovery of genetic variants associated with complex diseases. These studies present …