[HTML][HTML] Statistical analysis for genome-wide association study

P Zeng, Y Zhao, C Qian, L Zhang, R Zhang… - Journal of biomedical …, 2015 - ncbi.nlm.nih.gov
In the past few years, genome-wide association study (GWAS) has made great successes in
identifying genetic susceptibility loci underlying many complex diseases and traits. The …

A road map for efficient and reliable human genome epidemiology

JPA Ioannidis, M Gwinn, J Little, JPT Higgins… - Nature Genetics, 2006 - nature.com
Networks of investigators have begun sharing best practices, tools and methods for analysis
of associations between genetic variation and common diseases. A Network of Investigator …

Beyond odds ratios—communicating disease risk based on genetic profiles

P Kraft, S Wacholder, MC Cornelis, FB Hu… - Nature Reviews …, 2009 - nature.com
The brisk discovery of novel inherited disease markers by genome-wide association (GWA)
studies has raised expectations for predicting disease risk by analysing multiple common …

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

LE Mechanic, HS Chen, CI Amos… - Genetic …, 2012 - Wiley Online Library
Over the past several years, genome‐wide association studies (GWAS) have succeeded in
identifying hundreds of genetic markers associated with common diseases. However, most …

Bringing genome-wide association findings into clinical use

TA Manolio - Nature Reviews Genetics, 2013 - nature.com
Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …

Genomewide association studies and human disease

J Hardy, A Singleton - New England Journal of Medicine, 2009 - Mass Medical Soc
Genomewide Association Studies and Human Disease | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Association study designs for complex diseases

LR Cardon, JI Bell - Nature Reviews Genetics, 2001 - nature.com
Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

GWASdb: a database for human genetic variants identified by genome-wide association studies

MJ Li, P Wang, X Liu, EL Lim, Z Wang… - Nucleic acids …, 2012 - academic.oup.com
Recent advances in genome-wide association studies (GWAS) have enabled us to identify
thousands of genetic variants (GVs) that are associated with human diseases. As next …

[PDF][PDF] A short history of the genome-wide association study: where we were and where we are going

S Ikegawa - Genomics & informatics, 2012 - synapse.koreamed.org
Recent rapid advances in genetic research are ushering us into the genome sequence era,
where an individual's genome information is utilized for clinical practice. The most …

15 years of GWAS discovery: realizing the promise

A Abdellaoui, L Yengo, KJH Verweij… - The American Journal of …, 2023 - cell.com
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …