Association replication studies have a poor track record and, even when successful, often
claim association with different markers, alleles, and phenotypes than those reported in the …

Massively parallel whole-genome sequencing (WGS) data have ushered in a new era in
human genetics. These data are now being used to understand the role of rare variants in …

Genetic effects for common variants affecting complex disease risk are subtle. Single
genome-wide association (GWA) studies are typically underpowered to detect these effects …

Non-replication and inconsistency had been common features in the search for common
variants of candidate genes affecting the risk of complex diseases. They may continue to …

The identification of complex disease susceptibility loci through genome-wide association
studies (GWAS) has recently become possible and is now a method of choice for …

Recent genome-wide association studies (GWAS) have identified DNA sequence variations
that exhibit unequivocal statistical associations with many common chronic diseases …

The GWAS Central resource provides a toolkit for integrative access and visualization of a
uniquely extensive collection of genome-wide association study data, while ensuring safe …

Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …

Genomewide association studies are set to become the tool of the future for detection of
small-effect genes in complex diseases. It will therefore be necessary to calculate sufficient …

After nearly 10 years of intense academic and commercial research effort, large genome-
wide association studies for common complex diseases are now imminent. Although these …