Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …

Genome-wide association studies (GWASs) have successfully identified thousands of
genetic variants that are reliably associated with human traits. Although GWASs are …

Abstract Knowledge of inherited genetic variation has a fundamental impact on
understanding human disease. Unfortunately, our understanding of the functional …

Most common diseases and quantitative traits are heritable: determined in part by genetic
variation within the population. The inheritance is typically polygenic in that combined effects …

Much of the literature on genome-wide association (GWA) studies is based on the premise
that an important proportion of common diseases is heritable, and that this proportion is …

Genetic association studies are used to find candidate genes or genome regions that
contribute to a specific disease by testing for a correlation between disease status and …

In most complex diseases, much of the heritability remains unaccounted for by common
variants. It has been postulated that lower-frequency variants contribute to the remaining …

In the last 2 years, the effort to identify genes affecting common diseases and complex traits
has been accelerated through the use of genome-wide association studies (GWAS). The …

GWAS have been successful in identifying disease susceptibility loci, but it remains a
challenge to pinpoint the causal variants in subsequent fine-mapping studies. A …

Genic variants are more likely to alter gene function and affect disease risk than those that
occur outside genes. Variants in genes, however, might not be sufficiently covered by the …