Phenotypic misclassification (between cases) has been shown to reduce the power to detect
association in genetic studies. However, it is conceivable that complex traits are …

Clinical & Investigative Medicine (CIM) is receiving an increasing number of reports of
candidate-based association studies. The track record of such studies in the past has been …

About 10 years ago, after the first large-scale genome-wide association studies (GWAS)
were conducted to find genes associated with common complex diseases, investigators …

Large-scale association studies hold substantial promise for unraveling the genetic basis of
common human diseases. A well-known problem with such studies is the presence of …

Abstract The Human Genome Variation database of Genotype to Phenotype information
(HGVbaseG2P) is a new central database for summary-level findings produced by human …

Association studies offer a potentially powerful approach to identify genetic variants that
influence susceptibility to common disease 1, 2, 3, 4, but are plagued by the impression that …

Genetic association studies for multigenetic diseases are like fishing for the truth in a sea of
trillions of candidate analyses. Red herrings are unavoidably common, and bias might …

Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …

Empirical evidences suggest that both common and rare variants contribute to complex
disease etiology. Although the effects of common variants have been thoroughly assessed …

With the availability of dense maps of anonymous and frequent SNPs spanning the whole
human genome, genome-wide association studies are now becoming a reality. In this paper …