Power of association and linkage tests when the disease alleles are unobserved
IP Tu, AS Whittemore - The American Journal of Human Genetics, 1999 - cell.com
Genomewide association studies have been advocated as a promising alternative to
genomewide linkage scans for detection of small-effect genes in complex diseases …
genomewide linkage scans for detection of small-effect genes in complex diseases …
Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
With the availability of dense maps of anonymous and frequent SNPs spanning the whole
human genome, genome-wide association studies are now becoming a reality. In this paper …
human genome, genome-wide association studies are now becoming a reality. In this paper …
Genome‐wide association studies: quality control and population‐based measures
A Ziegler - Genetic epidemiology, 2009 - Wiley Online Library
Genome‐wide association studies, using hundreds of thousands of single‐nucleotide
polymorphism (SNP) markers, have become a standard approach for identifying disease …
polymorphism (SNP) markers, have become a standard approach for identifying disease …
GWIS: genome-wide inferred statistics for functions of multiple phenotypes
Here we present a method of genome-wide inferred study (GWIS) that provides an
approximation of genome-wide association study (GWAS) summary statistics for a variable …
approximation of genome-wide association study (GWAS) summary statistics for a variable …
A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design
JR Staley, E Jones, S Kaptoge… - European Journal of …, 2017 - nature.com
Logistic regression is often used instead of Cox regression to analyse genome-wide
association studies (GWAS) of single-nucleotide polymorphisms (SNPs) and disease …
association studies (GWAS) of single-nucleotide polymorphisms (SNPs) and disease …
How to interpret a genome-wide association study
TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
Evaluating statistical significance in two-stage genomewide association studies
DY Lin - The American Journal of Human Genetics, 2006 - cell.com
Genomewide association studies are being conducted to unravel the genetic etiology of
complex human diseases. Because of cost constraints, these studies typically employ a two …
complex human diseases. Because of cost constraints, these studies typically employ a two …
Disease and polygenic architecture: avoid trio design and appropriately account for unscreened control subjects for common disease
WJ Peyrot, DI Boomsma, BWJH Penninx… - The American Journal of …, 2016 - cell.com
Genome-wide association studies (GWASs) are an optimal design for discovery of disease
risk loci for diseases whose underlying genetic architecture includes many common causal …
risk loci for diseases whose underlying genetic architecture includes many common causal …
Genome‐wide association studies and the genetic dissection of complex traits
P Sebastiani, N Timofeev, DA Dworkis… - American journal of …, 2009 - Wiley Online Library
The availability of affordable high throughput technology for parallel genotyping has opened
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …
Enriching the analysis of genomewide association studies with hierarchical modeling
Genomewide association studies (GWAs) initially investigate hundreds of thousands of
single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further …
single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further …