Power of association and linkage tests when the disease alleles are unobserved

IP Tu, AS Whittemore - The American Journal of Human Genetics, 1999 - cell.com
Genomewide association studies have been advocated as a promising alternative to
genomewide linkage scans for detection of small-effect genes in complex diseases …

Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?

C Bourgain, E Génin, N Cox… - European journal of …, 2007 - nature.com
With the availability of dense maps of anonymous and frequent SNPs spanning the whole
human genome, genome-wide association studies are now becoming a reality. In this paper …

Genome‐wide association studies: quality control and population‐based measures

A Ziegler - Genetic epidemiology, 2009 - Wiley Online Library
Genome‐wide association studies, using hundreds of thousands of single‐nucleotide
polymorphism (SNP) markers, have become a standard approach for identifying disease …

GWIS: genome-wide inferred statistics for functions of multiple phenotypes

HA Nieuwboer, R Pool, CV Dolan, DI Boomsma… - The American Journal of …, 2016 - cell.com
Here we present a method of genome-wide inferred study (GWIS) that provides an
approximation of genome-wide association study (GWAS) summary statistics for a variable …

A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design

JR Staley, E Jones, S Kaptoge… - European Journal of …, 2017 - nature.com
Logistic regression is often used instead of Cox regression to analyse genome-wide
association studies (GWAS) of single-nucleotide polymorphisms (SNPs) and disease …

How to interpret a genome-wide association study

TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …

Evaluating statistical significance in two-stage genomewide association studies

DY Lin - The American Journal of Human Genetics, 2006 - cell.com
Genomewide association studies are being conducted to unravel the genetic etiology of
complex human diseases. Because of cost constraints, these studies typically employ a two …

Disease and polygenic architecture: avoid trio design and appropriately account for unscreened control subjects for common disease

WJ Peyrot, DI Boomsma, BWJH Penninx… - The American Journal of …, 2016 - cell.com
Genome-wide association studies (GWASs) are an optimal design for discovery of disease
risk loci for diseases whose underlying genetic architecture includes many common causal …

Genome‐wide association studies and the genetic dissection of complex traits

P Sebastiani, N Timofeev, DA Dworkis… - American journal of …, 2009 - Wiley Online Library
The availability of affordable high throughput technology for parallel genotyping has opened
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …

Enriching the analysis of genomewide association studies with hierarchical modeling

GK Chen, JS Witte - The American Journal of Human Genetics, 2007 - cell.com
Genomewide association studies (GWAs) initially investigate hundreds of thousands of
single-nucleotide polymorphisms (SNPs), and the most promising SNPs are further …