High trans-ethnic replicability of GWAS results implies common causal variants
UM Marigorta, A Navarro - PLoS genetics, 2013 - journals.plos.org
Genome-wide association studies (GWAS) have detected many disease associations.
However, the reported variants tend to explain small fractions of risk, and there are doubts …
However, the reported variants tend to explain small fractions of risk, and there are doubts …
Genome‐wide association studies and the genetic dissection of complex traits
P Sebastiani, N Timofeev, DA Dworkis… - American journal of …, 2009 - Wiley Online Library
The availability of affordable high throughput technology for parallel genotyping has opened
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …
the field of genetics to genome‐wide association studies (GWAS), and in the last few years …
Meta-analysis of genome-wide association studies with overlapping subjects
DY Lin, PF Sullivan - The American Journal of Human Genetics, 2009 - cell.com
Data from multiple genome-wide association studies are often analyzed together for the
purposes of combining information from several studies of the same disease or comparing …
purposes of combining information from several studies of the same disease or comparing …
Genome-wide gene and pathway analysis
Current GWAS have primarily focused on testing association of single SNPs. To only test for
association of single SNPs has limited utility and is insufficient to dissect the complex …
association of single SNPs has limited utility and is insufficient to dissect the complex …
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
Genome-wide association studies: a primer
There have been nearly 400 genome-wide association studies (GWAS) published since
2005. The GWAS approach has been exceptionally successful in identifying common …
2005. The GWAS approach has been exceptionally successful in identifying common …
Correcting “winner's curse” in odds ratios from genomewide association findings for major complex human diseases
H Zhong, RL Prentice - Genetic Epidemiology: The Official …, 2010 - Wiley Online Library
Genome‐wide association studies (GWAS) provide an important approach for identifying
common genetic variants that predispose to human disease. However, odds ratio (OR) …
common genetic variants that predispose to human disease. However, odds ratio (OR) …
Replication validity of genetic association studies
The rapid growth of human genetics creates countless opportunities for studies of disease
association. Given the number of potentially identifiable genetic markers and the multitude of …
association. Given the number of potentially identifiable genetic markers and the multitude of …
Towards a complete resolution of the genetic architecture of disease
After years of linear gains in the genetic dissection of human disease we are now in a period
of exponential discovery. This is particularly apparent for complex disease. Genome-wide …
of exponential discovery. This is particularly apparent for complex disease. Genome-wide …
Family-based designs for genome-wide association studies
J Ott, Y Kamatani, M Lathrop - Nature Reviews Genetics, 2011 - nature.com
Association mapping has successfully identified common SNPs associated with many
diseases. However, the inability of this class of variation to account for most of the supposed …
diseases. However, the inability of this class of variation to account for most of the supposed …