Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have
'Cushingoid'side effects including visceral obesity, muscle myopathy, hypertension, insulin …

The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess,
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …

The global epidemic of obesity and type-2 diabetes has heightened the need to understand
the mechanisms that contribute to its pathogenesis and also to design and trial novel …

The many similarities between the metabolic syndrome and Cushing's syndrome led to the
hypothesis that excess glucocorticoids (GC) are part of the pathogenesis linking their …

An impaired glucose metabolism, which often leads to the onset of diabetes mellitus (DM), is
a common complication of chronic exposure to exogenous and endogenous glucocorticoid …

Two isoforms of 11β-hydroxysteroid dehydrogenase (11β-HSD) interconvert the active
glucocorticoid, cortisol, and inactive cortisone. 11β-HSD1 acts predominantly as an oxo …

The metabolic syndrome describes a clustering of risk factors—visceral obesity,
dyslipidaemia, insulin resistance, and salt-sensitive hypertension—that increases mortality …

Due to its impact upon health and the economy, the mechanisms that contribute to the
pathogenesis of obesity and the metabolic syndrome are under intense scrutiny. In addition …

Context: The pathophysiological importance of glucocorticoids (GCs) is exemplified by
patients with Cushing's syndrome who develop hypertension, obesity, and insulin …

Systemic glucocorticoid excess, as exemplified by the Cushing syndrome, leads to obesity
and all further symptoms of the metabolic syndrome. The current obesity epidemic, however …