Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse
prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human …
prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human …
Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis
M Han, Z Liu, L Liu, X Huang, H Wang, W Pu, E Wang… - Nature Genetics, 2023 - nature.com
After severe heart injury, fibroblasts are activated and proliferate excessively to form
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …
Genetic regulation of fibroblast activation and proliferation in cardiac fibrosis
Background: Genetic diversity and the heterogeneous nature of cardiac fibroblasts (CFbs)
have hindered characterization of the molecular mechanisms that regulate cardiac fibrosis …
have hindered characterization of the molecular mechanisms that regulate cardiac fibrosis …
Noninvasive assessment of organ-specific and shared pathways in multi-organ fibrosis using T1 mapping
Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …
Epigenetic regulation of cardiac fibrosis
MS Stratton, TA McKinsey - Journal of molecular and cellular cardiology, 2016 - Elsevier
Fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue
scarring and organ dysfunction. In the heart, fibrosis may be reparative, replacing areas of …
scarring and organ dysfunction. In the heart, fibrosis may be reparative, replacing areas of …
Primary myocardial fibrosis as an alternative phenotype pathway of inherited cardiac structural disorders
Background: Myocardial fibrosis is a common postmortem finding among young individuals
with sudden cardiac death. Because there is no known single cause, we tested the …
with sudden cardiac death. Because there is no known single cause, we tested the …
[HTML][HTML] Current understanding of fibrosis in genetic cardiomyopathies
Myocardial fibrosis is the excessive deposition of extracellular matrix proteins, including
collagens, in the heart. In cardiomyopathies, the formation of interstitial fibrosis and/or …
collagens, in the heart. In cardiomyopathies, the formation of interstitial fibrosis and/or …
Myocardial interstitial fibrosis in heart failure: biological and translational perspectives
Myocardial interstitial fibrosis contributes to left ventricular dysfunction leading to the
development of heart failure. Basic research has provided abundant evidence for the …
development of heart failure. Basic research has provided abundant evidence for the …
Association between proteomic biomarkers and myocardial fibrosis measured by MRI: the multi-ethnic study of atherosclerosis
Background Cardiac magnetic resonance imaging (CMR) determines the extent of interstitial
fibrosis, measured by increased extracellular volume (ECV), and replacement fibrosis with …
fibrosis, measured by increased extracellular volume (ECV), and replacement fibrosis with …
A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity
G Palano, M Jansson, A Backmark, S Martinsson… - Journal of molecular and …, 2020 - Elsevier
A key feature in the pathogenesis of heart failure is cardiac fibrosis, but effective treatments
that specifically target cardiac fibrosis are currently not available. A major impediment to …
that specifically target cardiac fibrosis are currently not available. A major impediment to …