Competing protein-RNA interaction networks control multiphase intracellular organization
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly …
such as those associated with RNA processing, but the rules that dictate their assembly …
RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates
M Garcia-Jove Navarro, S Kashida, R Chouaib… - Nature …, 2019 - nature.com
Liquid–liquid phase separation is thought to be a key organizing principle in eukaryotic cells
to generate highly concentrated dynamic assemblies, such as the RNP granules. Numerous …
to generate highly concentrated dynamic assemblies, such as the RNP granules. Numerous …
[HTML][HTML] G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
for establishing and maintaining RNP granules with distinct composition, are unknown. One …
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
biomolecular condensates, eukaryotic cell structures that concentrate diverse …
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
S Boeynaems, AS Holehouse… - Proceedings of the …, 2019 - National Acad Sciences
Phase separation of multivalent protein and RNA molecules underlies the biogenesis of
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
biomolecular condensates such as membraneless organelles. In vivo, these condensates …
RNA-binding and prion domains: the Yin and Yang of phase separation
NL Gotor, A Armaos, G Calloni… - Nucleic acids …, 2020 - academic.oup.com
Proteins and RNAs assemble in membrane-less organelles that organize intracellular
spaces and regulate biochemical reactions. The ability of proteins and RNAs to form …
spaces and regulate biochemical reactions. The ability of proteins and RNAs to form …
High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate
BD Freibaum, J Messing, P Yang, HJ Kim… - Journal of Cell …, 2021 - rupress.org
Liquid–liquid phase separation (LLPS) is a mechanism of intracellular organization that
underlies the assembly of a variety of RNP granules. Fundamental biophysical principles …
underlies the assembly of a variety of RNP granules. Fundamental biophysical principles …
Liquid–liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences
Z Feng, B Jia, M Zhang - Biochemistry, 2021 - ACS Publications
Extensive studies in the past few years have shown that nonmembrane bound organelles
are likely assembled via liquid–liquid phase separation (LLPS), a process that is driven by …
are likely assembled via liquid–liquid phase separation (LLPS), a process that is driven by …
Sequence-encoded and composition-dependent protein-RNA interactions control multiphasic condensate morphologies
Multivalent protein-protein and protein-RNA interactions are the drivers of biological phase
separation. Biomolecular condensates typically contain a dense network of multiple proteins …
separation. Biomolecular condensates typically contain a dense network of multiple proteins …