The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …

▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

Neurotrophins and their Trk receptors play a crucial role in the development and
maintenance of the vertebrate nervous system, but to date no component of this signalling …

The neurotrophins represent a family of survival and differentiation factors that exert
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …

trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of …

The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …

Neurotrophins, such as NGF and BDNF, activate Trk receptor tyrosine kinases through
receptor dimerization at the cell surface followed by autophosphorylation and intracellular …

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related
neurotrophins. Here we present a developmental expression study of trk C, which encodes a …

Members of the Trk tyrosine kinase family have recently been identified as functional
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …

Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk
(also known as TrkA), TrkB, and TrkC, are responsible for mediating the trophic effects of the …