Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure
BA Firulli, RM George, J Harkin, KP Toolan… - Cardiovascular …, 2020 - academic.oup.com
Aims To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
[HTML][HTML] Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium
NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli… - Cell reports, 2014 - cell.com
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development
RM Barnes, BA Firulli, NJ VanDusen… - Circulation …, 2011 - Am Heart Assoc
Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …
essential for embryonic development. Given their requirement for cardiogenesis, it is …
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
DG McFadden, AC Barbosa, JA Richardson… - 2005 - journals.biologists.com
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
[HTML][HTML] Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function
JW Vincentz, KP Toolan, W Zhang, AB Firulli - PLoS genetics, 2017 - journals.plos.org
Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for
heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play …
heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play …
[HTML][HTML] HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development
F Laurent, A Girdziusaite, J Gamart, I Barozzi… - Cell reports, 2017 - cell.com
The HAND2 transcriptional regulator controls cardiac development, and we uncover
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …
Hand factors in cardiac development
RM George, AB Firulli - The Anatomical Record, 2019 - Wiley Online Library
Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration
YL Schindler, KM Garske, J Wang, BA Firulli… - …, 2014 - journals.biologists.com
Embryonic heart formation requires the production of an appropriate number of
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …
Gene Replacement Strategies to Test the Functional Redundancy of Basic Helix–Loop–Helix Transcription Factor
AB Firulli, BA Firulli, J Wang, RH Rogers… - Pediatric cardiology, 2010 - Springer
Basic helix–loop–helix (bHLH) transcription factors control developmental decisions for a
wide range of embryonic cell types. Hand1 and Hand2 are closely related bHLH proteins …
wide range of embryonic cell types. Hand1 and Hand2 are closely related bHLH proteins …