Abstract Type 1 diabetes (T1D; or insulin-dependent diabetes mellitus, IDDM) is an
autoimmune disease with both genetic and environmental components. In addition to the …

Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-
obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type …

During the past decade, the genetics of type 1 (insulin-dependent) diabetes mellitus (IDDM)
has been studied extensively and the disorder has become a paradigm for genetically …

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions,, finding
major pathways contributing to risk, with some loci shared across immune disorders,,. To …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

Type 1, or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease
associated with loss of tolerance to several pancreatic islet cell molecules, including insulin …

betes) havealso beenexaminedinthe searchfortypeIIdiabetessusceptibility genes. Althoughvariantshavebeenidentifiedinmany…
, onlyafewhavebeen showntoassociate withdiabetesorimpaired proteinfunction (Fig. 1) …

Genetic analysis of a mouse model of major histocompatability complex (MHC)-associated
autoimmune type 1 (insulin-dependent) diabetes mellitus (IDDM) has shown that the …

LOCI in the major histocompatibility complex (MHC) on chromo-some 6 and the insulin (INS)
region on chromosome 11 have been implicated in susceptibility to insulin-dependent …

We have searched the human genome for genes that predispose to type 1 (insulin-
dependent) diabetes mellitus using semi-automated fluorescence-based technology and …